Selected studies on foreign body impaction in goats with special reference to ultrasonography

Background and Aim: Diagnosis of foreign body impaction in ruminant is still of interest in most clinical studies. The main purpose of this study was to evaluate this condition using B-mode ultrasonography in addition to evaluation of clinical, hemato-biochemical and ruminal parameters in healthy and affected goats. Materials and Methods: Fifteen clinically normal goats and 15 goats with foreign body impaction were recruited in Menia El-Kamh abattoir. All animals were selected only when revealed negative for internal and external parasite. Thorough clinical, ultrasonographic examination and blood analysis were applied before slaughtering. Meanwhile, ruminal fluid and necropsy findings were assessed after slaughtering. Results: The prominent clinical signs in diseased group were inappetence, dullness, emaciation, weakness, scanty hard feces and tympany. Ultrasonographic examination of diseased goats revealed the presence of foreign body at left 11th-12th ICS. Foreign body in rumen appeared as hyperechoic band with acoustic shadowing. Significant reduction in ruminal wall thickness and biphasic reticular motility along with significant increase in monophasic reticular contraction and relaxation period were recorded in diseased goats when compared with control one. The erythrocytes count, hemoglobin content, hematocrit percent and albumin were significantly decreased in diseased goats when compared with healthy one. Moreover, ruminal fluid analysis of affected goats revealed significant decrease in ruminal pH and prolonged Methylene blue reduction time. Conclusions: Findings indicated that B-mode ultrasonography is a relatively simple and objective method for diagnosis of foreign body impaction in goats

Atrial electromechanical delay in post-COVID-19 postural orthostatic tachycardia: Innocent bystander or pathologic factor

Background: Post-COVID-19 syndrome represents a wide range of ongoing symptoms that persist beyond weeks or even months, after recovery from the acute phase. Postural orthostatic tachycardia (POT) is one of these symptoms with a poorly recognized underlying pathophysiology. Purpose: We aimed to investigate atrial electromechanical delay (AEMD), demonstrated by electrocardiographic P wave dispersion (PWD) and tissue Doppler echocardiography (TDE) in patients with POST-COVID-19 POT (PCPOT). Methods: 94 post-COVID-19 patients were enrolled and classified into two groups; PCPOT group, 34 (36.1%) patients, and normal heart rate (NR group), 60 (63.9%) patients. 31.9% of them were males and 68.1% were females, with a mean age of 35 ± 9 years. Both groups were compared in terms of PWD and AEMD. Results: As compared to the NR group, the PCPOT group showed a significant increase in PWD (49 ± 6 versus 25.6 ± 7.8, p < 0.001), higher CRP (37 ± 9 versus 30 ± 6, p = 0.04), prolonged left-atrial EMD, right-atrial EMD and inter-atrial EMD at (p = 0.006, 0.001, 0.002 respectively). Multivariate logistic regression analysis revealed that P wave dispersion (β 0.505, CI (0.224–1.138), p = 0.023), PA lateral (β 0.357, CI (0.214–0.697), p = 0.005), PA septal (β 0.651, CI. (0.325–0.861), p = 0.021), and intra-left atrial EMD (β 0.535, CI (0.353–1.346) p < 0.012) were independent predictors of PCPOT. Conclusion: Atrial heterogenicity in the form of prolonged AEMD and PWD seems to be a reasonable underlying pathophysiology of PCPOT. This could provide a new concern during the management and novel pharmacological approaches in these patients

New indole derivatives as multi-target anti-Alzheimer's agents; synthesis, biological evaluation and molecular dynamics - supporting material final.docx

   S1: 3D interaction diagram of donepezil, & compound 11 with AChE (4EY7). S2: 2D interaction diagram of compounds; donepezil, 5, 7 & 11 with BChE (6QAE). S3: 2D interaction diagram between NADPH-Oxidase (2CDU) & donepezil, compounds; 5, 7 & 11. S4: 3D interaction diagram of donepezil & active Compound 5 with NADPH-Oxidase (2CDU). S5: H1-NMR of compound 3 S6: C13-NMR of compound 3 S7: Mass spectrum of compound 3 S8: H1-NMR of compound 4 S9: C13-NMR of compound 4 S10: Mass spectrum of compound 4 S11: H1-NMR of compound 5 S12: C13-NMR of compound 5 S13: Mass spectrum of compound 5 S14: H1-NMR of compound 6 S15: C13-NMR of compound 6 S16: Mass spectrum of compound 6 S17: H1-NMR of compound 7 S18: C13-NMR of compound 7 S19: Mass spectrum of compound 7 S20: H1-NMR of compound 8 S21: C13-NMR of compound 8 S22: Mass spectrum of compound 8 S23: H1-NMR of compound 9 S24: C13-NMR of compound 9 S25: Mass spectrum of compound 9 S26: H1-NMR of compound 10 S27: C13-NMR of compound 10 S28: H1-NMR of compound 11 S29: C13-NMR of compound 11 S30: Mass spectrum of compound 11 S31: H1-NMR of compound 12 S32: C13-NMR of compound 12 S33: Mass spectrum of compound 12 S34: H1-NMR of compound 13 S35: C13-NMR of compound 13 S36: Mass spectrum of compound 13 S37: H1-NMR of compound 14 S38: C13-NMR of compound 14 S39: Mass spectrum of compound 14 S40: H1-NMR of compound 15 S41: C13-NMR of compound 15 S42: Results of in vitro Biological Evaluation </p

Genomics of Egyptian healthy volunteers: the EHVol study

ABSTRACT Comprehensive genomic databases offer unprecedented opportunities towards effective tailored strategies for the prevention and treatment of disease. The integration of genomic and phenotypic data from diverse ethnic populations is also key to advancements in precision medicine and novel diagnostic technologies. Current reference genomic databases, however, are not representative of the global human population, making variant interpretation challenging and uncertain, especially in underrepresented populations such as the North African population. To address this, a study of 391 Egyptian healthy volunteers (EHVols) was initiated as a milestone towards establishing the 1000 Egyptian Genomes project